Table 1.
50 significant age-related protein abundance changes in mouse hearts. Bold numbers indicate significance (FDR < 0.1). Ordered by lowest P-value in Young vs Old Control comparison. Full results can be found in Appendix 1
| Protein | Fold Change Relative to Old Control | ||
|---|---|---|---|
| Young | Old + ELAM | Old + NMN | |
| MFGE8 | 0.26 | 1.15 | 0.95 |
| PLIN5 | 3.36 | 0.62 | 0.79 |
| HSPB1 | 1.55 | 1.21 | 1.00 |
| MLYCD | 2.35 | 1.18 | 1.59 |
| Cox5b | 1.69 | 1.03 | 1.16 |
| STIP1 | 1.51 | 1.02 | 1.05 |
| COX5A | 1.51 | 1.06 | 1.18 |
| TNNC1 | 1.91 | 1.05 | 1.17 |
| PFDN5 | 1.87 | 0.99 | 1.06 |
| PLIN3 | 2.49 | 0.83 | 0.92 |
| TOM1 | 1.75 | 0.90 | 1.06 |
| AK3 | 1.73 | 0.99 | 0.97 |
| COA7 | 1.94 | 1.05 | 1.02 |
| NDRG2 | 2.40 | 1.01 | 1.10 |
| Cox8b | 22.74 | 0.61 | 4.60 |
| SERPINH1 | 2.74 | 1.48 | 1.66 |
| COQ9 | 1.95 | 1.10 | 1.14 |
| CKM | 1.54 | 0.85 | 0.91 |
| UCHL3 | 2.09 | 1.06 | 1.36 |
| EEF1D | 1.74 | 1.26 | 1.13 |
| HP | 0.07 | 1.25 | 0.54 |
| PFDN6 | 2.56 | 1.13 | 1.43 |
| AK1 | 1.42 | 1.00 | 1.02 |
| PPM1B | 2.05 | 1.20 | 1.30 |
| EIF3J | 2.07 | 0.95 | 1.26 |
| Mt2 | 0.24 | 1.83 | 1.12 |
| NDUFS8 | 1.69 | 0.87 | 0.88 |
| HPRT1 | 0.31 | 1.28 | 1.36 |
| RBBP4 | 2.67 | 1.40 | 1.62 |
| NSFL1C | 1.46 | 1.12 | 1.08 |
| RBM8A | 3.28 | 1.38 | 1.92 |
| TACO1 | 1.79 | 1.16 | 1.25 |
| GLRX3 | 1.60 | 1.24 | 1.03 |
| PDHX | 1.38 | 1.03 | 1.01 |
| PDIA6 | 1.86 | 1.08 | 0.87 |
| DDT | 9.24 | 1.39 | 0.97 |
| GRSF1 | 7.94 | 0.53 | 2.70 |
| COQ3 | 2.22 | 1.53 | 1.52 |
| AK4 | 2.39 | 1.04 | 1.05 |
| PTGDS | 0.29 | 1.23 | 1.05 |
| FBLN5 | 2.67 | 1.78 | 1.13 |
| PPA2 | 1.62 | 0.90 | 1.13 |
| HSPB2 | 1.56 | 1.26 | 1.30 |
| DGLUCY | 1.58 | 1.11 | 1.25 |
| CBX1 | 1.80 | 1.00 | 1.34 |
| CAPRIN1 | 1.57 | 1.21 | 1.40 |
| RILP | 3.79 | 1.30 | 1.89 |
| NDUFV2 | 1.30 | 1.00 | 1.11 |
| HSPA9 | 1.55 | 1.05 | 0.96 |
| COQ8A | 1.54 | 0.74 | 0.89 |