Table 1.
Echocardiography parameters in WT and 12/15LOX−/− aging mice
| WT (2 months) | 12/15LOX−/− (2 months) | 12/15LOX−/− (6 months) | 12/15LOX−/− (13 months) | |
|---|---|---|---|---|
| n | 10 | 10 | 10 | 14 |
| Body weight (g) | 25 ± 1 | 21 ± 1 | 24 ± 1 | 25 ± 1 |
| Heart rate (bpm) | 471 ± 12 | 499 ± 14 | 435 ± 16 | 462 ± 12 |
| EDD (mm) | 3.8 ± 0.07 | 3.5 ± .08 | 3.9 ± 0.09 | 3.9 ± 0.09 |
| ESD (mm) | 2.3 ± 0.07 | 2.2 ± .09 | 2.9 ± 0.08 | 2.9 ± 0.08 |
| Fractional shortening (%) | 39 ± 1 | 37 ± 1 | 26 ± 1*# | 26 ± 1*# |
| PWTs (mm) | 1.09 ± 0.03 | 1.03 ± 0.02 | 1.16 ± .07 | 1.08 ± 0.04 |
| GLS (%) | − 20 ± 1 | − 15 ± 2 | − 15 ± 2 | − 14 ± 2 |
| EDV (µl) | 49 ± 3 | 44 ± 3 | 56 ± 3*# | 68 ± 4*# |
| ESV (µl) | 21 ± 2 | 25 ± 2 | 29 ± 3 | 33 ± 2*# |
| Ejection fraction (%) | 58 ± 3 | 44 ± 2 | 49 ± 3 | 52 ± 2 |
| E/A | 1.6 ± 0.09 | 1.3 ± 0.04 | 1.4 ± 0.08 | 1.4 ± 0.05 |
Values are mean ± SEM; n indicates sample size. bpm beats per minute, EDD end-diastolic dimension, ESD end-systolic dimension, ESV end-systolic volume, EDV end-diastolic volume, GLS global longitudinal strain, PWT Posterior wall thickness, S systole, mm millimeter, E velocity of early mitral flow, A velocity of late mitral flow. *p < 0.05 vs. day 0 wild-type (WT 2 months) l; #p < 0.05 vs. 12/15LOX−/− 2 months