Fig. 4.

A and B show the pseudotime continuum from a Converter_pre (dots on the right side) to a Converter_post (dots on the left side) for the subjects that developed AD during the period of observation. Dots represent subjects: in A, blue dots are subjects at their Converter_pre condition and red dots are those at their Converter_post condition. In B, blue dots show the Converter_post condition for subjects; the other colors show different Converter_pre stages. C A heatmap expression matrix for significant DE TEs at the 3 (early, mid, and late) Converter_pre stages in addition to the Converter_post phase