Table 3.

Comparing the goodness-of-fit between linear mixed-effect models for composite cognitive score¹ by addition of plasma amyloid-beta and other biomarkers to model with demographic factors

Model	AIC	ΔAIC
Demographic factors: age, sex, education, MAPT group, BMI	2602.2	Ref
Plus Aβ42/40	2592.9	-9.3	Ref
Plus Aβ42/40, GDF15, MCP12	2575.1	-27.1	-17.8

Aβ, amyloid-beta; BMI, body mass index; GDF15, growth differentiation factor 15; MAPT, Multidomain Alzheimer Preventive Trial; MCP1, monocyte chemoattractant protein 1

¹Based on the z score of four cognitive tests: free and total recall of the Free and Cued Selective Reminding test, ten MMSE orientation items, Digit Symbol Substitution Test, and Category Naming Test

²The multi-biomarker combination of the best-fitting linear mixed-effect model; the goodness-of-fit of the models with other biomarker combinations are provided in the supplementary materials