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. 2022 Mar 14;44(3):1269–1293. doi: 10.1007/s11357-022-00533-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Two heatmaps showing the expression levels of the 3436 differentially expressed genes (DEGs) together with a cluster analysis of the individuals (shown on top of each heatmap) based on the DEGs. Here, the CL1_eto1 animal was excluded from the differential gene expression analysis. a DEGs with small (< 50%) fold change differences (2200 genes). b DEGs with large fold change differences (1236 genes). Genes with > 50% differences in fold change were classified as highly differentially expressed genes