Table 2.

The association between levels of educational attainment and dementia risk

	Levels of educational attainment
	High	Intermediate	Low	P-trend
Cases (n, %)	294 (0.6)	431 (0.8)	757 (1.0)
Age and sex adjusted	1 (reference)	1.23 (1.06–1.43)	1.54 (1.34–1.76)	< 0.001
Multivariable adjusteda	1 (reference)	1.20 (1.03–1.39)	1.36 (1.18–1.56)	< 0.001
Multivariable adjusteda + number of APOE e4 allelesb	1 (reference)	1.20 (1.03–1.39)	1.35 (1.18–1.56)	< 0.001
Multivariable adjusteda + PRSb	1 (reference)	1.20 (1.03–1.39)	1.35 (1.17–1.55)	< 0.001

^aAdjusted for age, sex, Townsend deprivation index, moderating drinking, current smoking, healthy diet score, obesity, diabetes, hypertension, depression, social isolation, hearing problem, regular physical activity, high cholesterol, cardiovascular disease, and traumatic brain injury

^bFurther adjusted for the first 10 genetic principal components, relatedness, and genotyping array