Table 5.
Receiver operating characteristic curve analyses for predicting motor or cognitive progression in patients with Parkinson’s disease
| Covariates | Motor progression | Cognitive progression | ||
|---|---|---|---|---|
| AUC (95% CI) | p value | AUC (95% CI) | p value | |
| Basic model (age, sex, and baseline H-Y stage or MMSE score) | 0.759 (0.601–0.916) | 0.006** | 0.659 (0.403–0.915) | 0.160 |
| Model 1, basic model and α-synuclein | 0.951 (0.886–1.000) | < 0.001** | 0.869 (0.746–0.992) | 0.001** |
| Model 2, basic model and NfL | 0.906 (0.806–1.000) | < 0.001** | 0.707 (0.464–0.950) | 0.066 |
| Model 3, basic model and VDdM_parafovea and VDrID | 0.780 (0.629–0.931) | 0.003** | 0.866 (0.744–0.988) | 0.001** |
| Full model, basic model and α-synuclein, NfL, VDdM_parafovea and VDrID | 0.977 (0.933–1.000) | < 0.001** | 0.962 (0.901–1.000) | < 0.001** |
AUC, Area under the curve; CI, confidence interval; H-Y stage, Hoehn-and-Yahr stage; NfL, neurofilament light chain
*Statistically significant, P < 0.05; **P < 0.01