Fig. 4.

Long-term exercise training alleviates neuronal damage, apoptosis, and degeneration in TgF344-AD rats. Representative confocal microscopy images of MAP2 (A) and MBP (B)

taken from the cortex and hippocampus. The intensity of the immunoreactivity associated with MAP2 was quantified. C The number of apoptotic cells as measured by TUNEL staining. D Neuronal degeneration was assessed by F-Jade C staining. Scale bar = 10 μm. All data are expressed as mean ± SEM (n = 6). *P < 0.05 versus WT group, ^#P < 0.05 versus AD group