Table 5.
Sensitivity analysis per hormonal outcome with all groups or only adolescents (> 12 years old)
| Outcome | Study group | Mean difference [95% CI] | Overall effect |
|---|---|---|---|
| GH | All studies (primary main effect) | 0.48 ng/mL (− 0.02, 0,99) | Z = 1.87, p = 0.06 |
|
Only adolescents (> 12 years old) |
0.59 ng/mL (0.03, 1.15) | Z = 2.05, p = 0.04 | |
| IGF-I | All studies (primary main effect) | − 22.9 ng/mL (− 47.92, 2.12) | Z = 1.79, p = 0.07 |
|
Only adolescents (> 12 years old) |
− 18.11 ng/mL (− 46.75, 10.54) | Z = 1.24, p = 0.22 | |
| Testosterone | All studies (primary main effect) | 0.84 nmol/L (− 0.22, 1.90) | Z = 1.54, p = 0.12 |
|
Only adolescents (> 12 years old) |
1.56 nmol/L (− 0.82, 3.93) | Z = 1.28, p = 0.20 | |
| SHBG | All studies (primary main effect) | − 5.58 nmol/L (− 19.39, 8.23) | Z = 0.79, p = 0.43 |
|
Only adolescents (> 12 years old) |
0.70 nmol/L (− 16.41, 17.81) | Z = 0.08, p = 0.94 | |
| Cortisol | All studies (primary main effect) | − 17.40 nmol/L (− 88.50, 53.70) | Z = 0.48, p = 0.63 |
|
Only adolescents (> 12 years old) |
− 43.32 nmol/L (− 108.5, 21.89) | Z = 1.30, p = 0.19 |