Table 1.

List of genetic mutations and associated syndromes in multiple primary malignancies of breast and gynecologic cancers.

Disease	Gene	Associated syndrome
BC and OC	BRCA1/BRCA2	Hereditary breast and ovarian cancer (13)
	MSH6	Lynch syndrome (13)
	ATM	Ataxia–telangiectasia (35)
	PALB2	Fanconi anemia (35)
	CDKN2A	Familial atypical multiple mole melanoma syndrome (13)
	STK11	Peutz–Jeghers syndrome (13)
	RAD51C/RAD51D	–
BC and EC	p53	–
	HER-2	–
	PTEN	Cowden syndrome (13)
	IMP3	–
BC, EC and OC	MLH1, MSH2, MSH6	Lynch syndrome (13)