Figure 3.

The presence of the glyoxylate and dicarboxylate metabolism in reaction analysis and the individual models

(A) A pathway showing four of the reactions upregulated in the three diseases. Red arrows indicate reactions from the glyoxylate and dicarboxylate metabolism, purple arrows indicate reactions from the Butanoate metabolism. On the right, the bar-plot shows the enrichment of these four reactions in each disease.

(B) Reaction presence in the models. Reactions were only considered if they were significant (Benjamini-Hochberg, Q < 0.01) in every disease and there was over 20% difference in the abundance between the presence of the increased MSPs and decreased MSPs. Red shows the reaction is present in the model, blank white shows the reaction is absent.