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. 2022 Jun 8;12:797453. doi: 10.3389/fonc.2022.797453

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Copyright © 2022 Marvin, Spaans, de Kroon, Slieker, Khelil, ten Dijke, Ritsma and Jordanova

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaplan Meier curves for recurrence free survival (RFS) and disease specific survival (DSS) for SMAD4_null and TβR2 _null AC patients samples. Kaplan Meier curves for RFS and DSS of the institutional AC cohort, dichotomized based on SMAD4_null (A), TβR2_null (C), TβR2_null or SMAD4_null (E) expression. The number of patient samples included in each group is indicated between brackets in the legend. P values based on log-rank test, bold indicates significance (p ≤ 0.05). Protein expression of TβR2, SMAD4 (nuclear and cytoplasmic), PAI-1 and MMP2 were compared in TβR2 wild type versus null (B) and SMAD4 wild type versus null (D). Significance is indicated with p<0.05 (*) and p<0.0001 (****).