Table 2.
Protein expression scores.
| Protein: | TβR1 | TβR2 | pSMAD2 | SMAD4 (nuclear) | SMAD4 (cytoplasm) | PAI-1 | αvβ6 | MMP2 | MMP9 | |
|---|---|---|---|---|---|---|---|---|---|---|
| n=60 | n=58 | n=55 | n=53 | n=53 | n=52 | n=61 | n=62 | n=62 | ||
| Percentage | <1% | 0 (0) | 5 (9) | 1 (2) | 17 (32) | 7 (13) | 6 (12) | 13 (21) | 0 (0) | 37 (60) |
| 1-5% | 5 (8) | 1 (2) | 11 (20) | 11 (21) | 2 (4) | 12 (23) | 18 (29) | 4 (7) | 17 (27) | |
| 6-25% | 2 (4) | 5 (9) | 12 (22) | 14 (26) | 4 (8) | 7 (13) | 17 (28) | 9 (15) | 8 (13) | |
| 26-50% | 5 (8) | 6 (10) | 7 (13) | 8 (15) | 12 (23) | 7 (13) | 4 (7) | 6 (10) | 0 (0) | |
| 51-75% | 9 (15) | 16 (27) | 6 (11) | 1 (2) | 4 (8) | 14 (27) | 4 (7) | 17 (27) | 0 (0) | |
| >75% | 39 (65) | 25 (43) | 18 (33) | 2 (4) | 24 (45) | 6 (12) | 5 (8) | 26 (42) | 0 (0) | |
| Intensity | Negative | 0 (0) | 5 (9) | 1 (2) | 17 (32) | 7 (13) | 6 (12) | 13 (21) | 0 (0) | 37 (60) |
| Dull | 28 (47) | 18 (31) | 18 (33) | 19 (36) | 21 (40) | 33 (63) | 26 (43) | 12 (19) | 16 (26) | |
| Clear | 32 (53) | 28 (48) | 27 (49) | 17 (32) | 20 (38) | 13 (25) | 18 (29) | 29 (47) | 9 (15) | |
| Intense | 0 (0) | 7 (12) | 9 (16) | 0 (0) | 5 (9) | 0 (0) | 4 (7) | 21 (34) | 0 (0) | |
| Total score | Negative (0) | 0 (0) | 5 (9) | 1 (2) | 17 (32) | 7 (13) | 6 (11) | 13 (21) | 0 (0) | 37 (60) |
| Weak (2-4) | 11 (18) | 10 (17) | 24 (44) | 26 (49) | 16 (30) | 26 (50) | 36 (59) | 15 (24) | 25 (40) | |
| Moderate (5-6) | 19 (32) | 25 (43) | 12 (22) | 8 (15) | 9 (17) | 15 (29) | 8 (13) | 18 (29) | 0 (0) | |
| Strong (7-8) | 30 (50) | 18 (31) | 18 (32) | 2 (4) | 21 (40) | 5 (10) | 4 (7) | 29 (47) | 0 (0) |
Protein expression scores. Immunohistochemical assays were evaluated by the scoring system from Ruiter et al (36). Values are presented in number of patients (percentage).