Table 3.
Univariate survival analysis.
| Protein | Expression | n | RFS | Hazard Ratio | p value | DSS | Hazard Ratio | p value |
|---|---|---|---|---|---|---|---|---|
| TβR1 | low (≤5) | 20 | 65% | 0.4 (0.1-1.1) | 0.070 | 70% | 0.5 (0.1-1.4) | 0.156 |
| high (>5) | 40 | 85% | 85% | |||||
| TβR2 | low (≤4) | 15 | 46% | 0.1 (0.04-0.41) | <0.001 | 53% | 0.2 (0.05-0.52) | 0.001 |
| high (>4) | 43 | 91% | 91% | |||||
| pSMAD2 | low (≤5) | 32 | 69% | 0.3 (0.1-1.2) | 0.057 | 72% | 0.3 (0.1-1.3) | 0.082 |
| high (>5) | 23 | 91% | 91% | |||||
| SMAD4 nucl | low (≤2) | 27 | 74% | 0.3 (0.05-1.19) | 0.060 | 74% | 0.1 (0.02-1.01) | 0.021 |
| high (>2) | 26 | 92% | 96% | |||||
| SMAD4 cyto | low (≤6) | 32 | 75% | 0.2 (0.02-1.32) | 0.053 | 78% | 0.2 (0.02-1.5) | 0.079 |
| high (>6) | 21 | 95% | 95% | |||||
| PAI-1 | low (≤6) | 47 | 83% | 4.5 (1.2-17.2) | 0.016 | 85% | 4.2 (1.1-16.5) | 0.023 |
| high (>6) | 5 | 40% | 40% | |||||
| Avβ6 | low (≤4) | 49 | 84% | 2.4 (1.0-6.1) | 0.055 | 86% | 2.6 (1.1-6.6) | 0.046 |
| high (>4) | 12 | 58% | 58% | |||||
| MMP2 | low (≤6) | 33 | 82% | 1.0 (0.3-3.0) | 0.800 | 79% | 1.2 (0.4-3.6) | 0.993 |
| high (>6) | 29 | 79% | 79% | |||||
| MMP9 | negative (0) | 37 | 76% | 0.6 (0.2-2.0) | 0.407 | 78% | 0.8 (0.2-2.2) | 0.517 |
| positive (>0) | 25 | 84% | 84% |
Univariate survival analysis. Univariate survival analysis for RFS and DSS for all TGF-β pathway associated proteins analysed in the present study. Values are calculated by Log Rank (Mantel-Cox) test. RFS, recurrence free survival; DSS, disease-free survival. Bold values indicate significance (p < 0.05).