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. 2022 Jun 8;12:797453. doi: 10.3389/fonc.2022.797453

Table 4.

Protein expression scores; comparison between AC and SCC.

AC SCC p value
    n (%) n (%)
pSMAD2 n 56 65 <0.001
Weak/neg (<25%) 24 (43) 3 (5)
Moderate (25-50%) 7 (13) 8 (12)
Strong (>50%) 25 (45) 54 (83)
SMAD4 (nuclear) n 54 62 <0.001
Weak/neg (<25%) 29 (54) 7 (11)
Moderate (25-50%) 14 (26) 30 (48)
Strong (>50%) 11 (20) 25 (40)
PAI-1 n 53 85 <0.001
Weak (2-4) 32 (60) 2 (2)
Moderate (5-6) 16 (30) 27 (32)
Strong (7-8) 5 (9) 56 (66)
Avβ6 n 62 64 <0.001
Weak (2-4) 50 (81) 11 (17)
Moderate (5-6) 8 (13) 24 (38)
Strong (7-8) 4 (6) 29 (45)
MMP2 n 62 21 0.002
Low (<=6) 33 (53) 18 (86)
High (>6) 29 (47) 3 (14)
MMP9 n 62 21 0.570
Low (<=6) 37 (60) 14 (67)
High (>6) 25 (40) 7 (33)

Protein expression scores. A comparison between AC and SCC of protein expression scores of pSMAD2, nuclear SMAD4, PAI-1, αvβ6, MMP2 and MMP9. Values are presented in number of patients (percentage). P-values are calculated using Chi-squared test. Bold value indicates significance (p <0.05). AC, adenocarcinoma; SCC, squamous cell carcinoma.