Table 1.

Concentrations achieved in urine and serum after a specific dose application for individual quinolones.

Quinolone	Dose [mg]	Concentrations achieved in the urine [µg/ml]	Concentrations achieved in serum [µg/ml]	Reference
Nalidixic acid	1,000	100	27.3	(24)
Pipemidic acid	100	400	1.23	(25)
	400	––––	3.64	(26)
	500	900	3.38	(25)
Ciprofloxacin	250	205–261	1.35–1.42	(27)
	500	255–518	2.60–2.89
	750	243–846	3.41–4.21
Ofloxacin	400	119	5.5	(28)
Fleroxacin	200	>200	––––	(29)
	100	68	2.9	(30)
	400	224	4.2
	800	490	9.4
	1,200	715	11.9
Norfloxacin	200	200	0.75	(31)
	400	478	1.58
	800	697	2.41
	1,200	992	3.15
	1,600	1045	3.87
Enoxacin	200	119–685	1.83	(32)
	800	379–1287	6.58
Lomefloxacin	100	104–713*	1.11	(33)
	200		2.46
	400		3.02
	600		4.79
	800		7.46
Pefloxacin	400	––––	3.66–9.06	(34)
	800	219	––––	(35)
Levofloxacin	500	406	5.61	(36)
Grepafloxacin	400	15.4	1.5	(37)
Gatifloxacin	400	111–649	1.53–2.46	(38)
Sparfloxacin	400	5.4–19.9	1.2–1.9	(39)
Trovafloxacin	200	––––	3.2	(40)
	300	7.3	3.0
Moxifloxacin	400	127	6.80	(41)
Gemifloxacin	160	––––	0.92	(42)
	320	55	2.01
	480	––––	2.0
	640	––––	3.03
Finafloxacin	25	––––	0.24	(43)
	50	––––	0.44
	100	0.1–101	1.32
	200	0.5–166	1.90
	400	1.4–328	5.06
	800	0.7–257	11.1

^*These values are range of concentrations achieved in urine for all tested doses of lomefloxacin.