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. 2022 Jun 8;12:899404. doi: 10.3389/fonc.2022.899404

Table 1b.

Comparisons of radiological features in the training and validation sets.

Characteristic Training set (N = 133) Validation set (N = 57) Pinter
ER (N = 56) non-ER (N = 77) Pintra ER (N = 24) non-ER (N = 33) Pintra
Tumor size (cm),
mean (range)
3.15 (2.70, 4.10) 3.00 (2.27, 4.00) 0.219 3.60 (2.95, 4.50) 3.10 (2.30, 4.05) 0.089 0.288
Cirrhosis, no. (%) 0.011 0.001 0.922
Present 42 (75.00%) 41 (53.25%) 21 (87.50%) 15 (45.45%)
Absent 14 (25.00%) 36 (46.75%) 3 (12.50%) 18 (54.55%)
Intratumoral fat, no. (%) 0.234 0.838 0.664
Present 6 (10.71%) 14 (18.18%) 5 (20.83%) 5 (15.15%)
Absent 50 (89.29%) 63 (81.82%) 19 (79.17%) 28 (84.85%)
Lesion location, no. (%) 0.337 0.085 0.181
Left lobe 8 (14.29%) 20 (25.97%) 2 (8.33%) 7 (21.21%)
Right lobe 44 (78.57%) 53 (68.83%) 22 (91.67%) 22 (66.67%)
Left and right lobes 1 (1.79%) 2 (2.60%) 0 (0.00%) 4 (12.12%)
Caudate lobe 3 (5.36%) 2 (2.60%) 0 (0.00%) 0 (0.00%)
Shape, no. (%) 0.753 0.426 0.727
Regular 29 (51.79%) 42 (54.55%) 12 (50.00%) 20 (60.61%)
Irregular 27 (48.21%) 35 (45.45%) 12 (50.00%) 13 (39.39%)
Radiological capsule 0.753 0.93 0.498
Complete 32 (57.14%) 45 (58.44%) 15 (62.50%) 21 (63.64%)
Absence or incomplete 24 (42.86%) 32 (41.56%) 9 (37.50%) 12 (36.36%)
Lesion margin, no. (%) 0.007 0.929 0.352
Smooth 35 (62.50%) 64 (83.12%) 20 (83.33%) 26 (78.79%)
Non-smooth 21 (37.50%) 13 (16.88%) 4 (16.67%) 7 (21.21%)
DWI intensity, no. (%) 0.494 0.919 0.79
Hyperintense 47 (83.93%) 65 (84.42%) 21 (87.50%) 28 (84.85%)
Slightly hyperintense 9 (16.07%) 12 (15.58%) 3 (12.50%) 5 (15.15%)
Enhancement pattern, no. (%) 0.046 0.181 0.432
Wash in and wash out 42 (75.00%) 57 (74.03%) 22 (91.67%) 24 (72.73%)
Gradual enhancement 4 (7.14%) 0 (0.00%) 0 (0.00%) 0 (0.00%)
Persistent enhancement 3 (5.36%) 11 (14.29%) 1 (4.17%) 2 (6.06%)
No or minimal enhancement 7 (12.50%) 9 (11.69%) 1 (4.17%) 7 (21.21%)
Arterial peritumoral enhancement, no. (%) 0.037 0.204 0.606
Present 9 (16.07%) 4 (5.19%) 5 (20.83%) 2 (6.06%)
Absent 47 (83.93%) 73 (94.81%) 19 (79.17%) 31 (93.94%)

PIntra indicates whether significant differences exist between the two groups. PInter represents whether significant differences exist between the two sets.

AFP, alpha-fetoprotein; ALT, alanine transaminase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; GGT, gamma-glutamyl transpeptidase; TBIL, total bilirubin; DBIL, direct bilirubin; IBIL, indirect bilirubin; TP, total protein; ALB, albumin; G, globulin; PLT, platelets; PT, prothrombin time; MVI, microvascular invasion; ER, early recurrence; IQR, interquartile range.