Table 2.
Univariate and multivariate analysis of association of PD-L2 and prognostic factors with overall survival in LGGs based on the TCGA and CGGA databases.
| Predictor | TCGA | CGGA | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariateanalysis | |||||
| HR (95%CI) |
P-value | HR (95% CI) |
P-value | HR (95% CI) |
P-value | HR (95% CI) |
P-value | |
|
Age
(>40) |
2.889 (2.009-4.155) |
<0.001 | 2.942 (1.890-4.580) | <0.001 | 1.150 (0.849-1.556) |
0.367 | ||
|
Gender
(Male) |
1.124 (0.800-1.580) | 0.499 | 1.276 (0.936-1.739) |
0.123 | ||||
|
WHO grade
(III vs II) |
3.059 (2.046-4.573) | <0.001 | 1.992 (1.277-3.107) | 0.002 | 3.041 (2.128-4.347) |
<0.001 | 3.159 (2.191-4.555) |
<0.001 |
|
IDH mutation
(Wildtype) |
5.385 (3.777-7.679) | <0.001 | 2.965 (1.813-4.848) | <0.001 | 2.078 (1.493-2.892) |
<0.001 | 1.573 (1.091-4.555) |
0.015 |
| 1p/19q codeletion | 0.401 (0.256-0.629) | <0.001 | 0.816 (0.431-1.546) | 0.533 | 0.377 (0.256-0.555) |
<0.001 | 0.595 (0.324-1.093) |
0.094 |
| Histological type | 0.577 (0.392-0.848) | 0.005 | 1.092 (0.642-1.856) | 0.745 | 0.511 (0.394-0.662) |
<0.001 | 0.820 (0.535-1.259) |
0.365 |
| PD-L2 | 2.794 (2.163-3.610) | <0.001 | 1.939 (1.355-2.775) | <0.001 | 1.738 (1.420-2.128) |
<0.001 | 1.384 (1.097-1.747) |
0.006 |