TABLE 1.

Multiple mutations in MSCs induce leukemogenesis.

Mice Model	Mutant gene	Labeling strategy	Phenotype	References
pRbfl/fl Mx1-cre	Rb	Mesenchymal cells	MPN	Walkley et al. (2007b)
RARγ−/-	RARγ	BMM	MPN	Walkley et al. (2007a)
Mibfl/fl MMTV-cre	Notch	Mesenchymal cells	MPN	Kim et al. (2008); Wang et al. (2014)
Mibfl/fl Mx1-cre
RBPJfl/fl Mx1-cre
Dicerfl/fl Osx-GFP-Cre	Dicer Sbds	osteoprogenitors	MDS	Raaijmakers et al. (2010); Zambetti et al. (2016)
Sbdsfl/fl Osx-GFP-Cre
PTPN11fl/fl Nestin-cre	PTPN11	Mesenchymal cells	MPN	Dong et al. (2016)