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. 2022 Jun 8;10:909696. doi: 10.3389/fcell.2022.909696

TABLE 1.

Histone Marks that are involved in DSB repair choice in mammalian cells.

Histone marks Writers Readers Erasers Outcome of repair
H2AK13/15ub RNF168 (Gatti et al., 2012; Mattiroli et al., 2012) 53BP1 (Fradet-Turcotte et al., 2013; Wilson et al., 2016), BRCA1-BARD1 (Becker et al., 2021; Krais et al., 2021), RAD18, RNF168, RNF169 (Hu et al., 2017; Kitevski-LeBlanc et al., 2017) USP51 (Wang et al., 2016), USP44 (Mosbech et al., 2013), USP11 (Ting et al., 2019), USP3 (Sharma et al., 2014) NHEJ, HR
H2BK120ac SAGA (Clouaire et al., 2018) Unknown Unknown HR
H2AK127/129ub BRCA1-BARD1 (Kalb et al., 2014; Hu et al., 2021; Witus et al., 2021) SMARCAD1 (Densham et al., 2016) USP48 (Uckelmann et al., 2018; Densham and Morris, 2019) HR
H3K4me2 SETD1A (Yilmaz et al., 2021) Unknown LSD1 (Shi et al., 2004; Yilmaz et al., 2021), JARID1 family proteins, NO66 (Højfeldt et al., 2013) HR
H3K9me3 SUV39H1/2, SETDB1 (Alagoz et al., 2015) HP1 (Alagoz et al., 2015), Tip60/KAT5 (Jacquet et al., 2016) JHDM3A (Klose et al., 2006), GASC1 (Cloos et al., 2006) HR
H3K27me3 EZH2 (Abu-Zhayia et al., 2018) Unknown UTX/KDM6A, UTY/KDM6C, JMJD3/KDM6B (Agger et al., 2007; De Santa et al., 2007; Walport et al., 2014)
H3K36me2 SETMAR (Fnu et al., 2011), SETD2 (Carvalho et al., 2014; Pfister et al., 2014) LEDGF/p75 (Daugaard et al., 2012; Pradeepa et al., 2012) JHDM1 (Tsukada et al., 2006) NHEJ, HR
H3K36me3 SETD2 (Carvalho et al., 2014; Pfister et al., 2014) LEDGF/p75 (Daugaard et al., 2012; Pradeepa et al., 2012), MRG15 (Bleuyard et al., 2017), PHF1 (Musselman et al., 2012; Musselman et al., 2013) JHDM3A (Klose et al., 2006), GASC1 (Cloos et al., 2006), JMJD2A/KDM4A (Mallette et al., 2012; Pfister et al., 2014) HR
H3K79me2 DOT1L/KMT4 (Wakeman et al., 2012; Zhou et al., 2016) Unknown KDM2B/FBXL10 (Kang et al., 2018) NHEJ
H4K12ac Tip60/KAT5 (Umehara et al., 2010) BRD2 (Gursoy-Yuzugullu et al., 2017) Unknown NHEJ
H4K16ac Tip60/KAT5 (Tang et al., 2013) Unknown HDAC1, HDAC2 (Miller et al., 2010; Hsiao and Mizzen, 2013), SIRT1 (Vaquero et al., 2004), SIRT2 (Vaquero et al., 2006) HR
H4K20me0 Unknown BRCA1-BARD1 (Nakamura et al., 2019) Unknown HR
H4K20me1/2 SET8/KMT5A (Fang et al., 2002; Nishioka et al., 2002), SUV4-20H1/2 (Schotta et al., 2004) 53BP1 (Botuyan et al., 2006; Wilson et al., 2016), MBTD1 (Jacquet et al., 2016) PHF8 (Liu et al., 2010; Qi et al., 2010), JMJD2A/KDM4A (Mallette et al., 2012) NHEJ, HR
H4K20me3 SUV4-20H1/2 (Schotta et al., 2004; Svobodová Kovaříková et al., 2018) 53BP1 (Svobodová Kovaříková et al., 2018) PHF2 (Stender et al., 2012), hHR23 A/B (Cao et al., 2020) NHEJ
H4K31uf UFM1 (Qin et al., 2019) STK38 (Qin et al., 2020) Unknown HR