Table 1.
A list of MS/MS approaches for characterization of complex lipids at the levels of C=C location and sn-position
| Structure Information | MS Approach | Lipids | Samples | Reference |
|---|---|---|---|---|
| C=C locations | Shotgun PB-MS/MS | FA and GPL | Lipid extracts | (58) |
| LC-PB-MS/MS | FA and GPL | Lipid extracts, plasma samples | (59, 60, 61, 65) | |
| MALDI-PB-MS/MS | GPL and glycosphingolipid, | Mouse brain tissue | (70, 114) | |
| UVPD-MS | PC, cardiolipin, FA, sphingolipid, SM, TG | E. coli and human papillary thyroid carcinoma extracts | (35, 36, 38, 115) | |
| LC-UVPD-MS | FA and GPL | Bovine liver and porcine brain extracts | (49, 63) | |
| DESI-UVPD-MS | PC | Brain tissue, lymph node tissue | (40) | |
| OzID-MS | GPL, SM, TG | Lipid extracts | (27, 31) | |
| LC-OzID-MS | PC, PE, SM | Human plasma | (32) | |
| epoxidation-MS/MS | FA and GPL | Bovine liver extract, human plasma, yeast extract, serum samples | (63, 72, 73, 76) | |
| epoxidation-LC-MS/MS | FA and GPL | Human serum | (76) | |
| epoxidation-DESI-MS/MS | FA and GPL | Human serum, mouse adipocytes, and cancer tissue sections | (76) | |
| epoxidation-MALDI-MS/MS | FA | Cancer tissue samples, human cell lines | (63) | |
| HAD/OAD- MS/MS | PC and LPC | Standards | (56) | |
| sn-positions | (+Na+) PB-MS3 | GPL | Human breast cancer cells | (66) |
| (+Na+) OzID-MS3 | GPL | Cow brain and kidney extracts | (96, 98) | |
| (+Na+) UVPD-MS3 | GP | Bovine liver and porcine brain extracts | (34) | |
| (+HCO3-) PB-MS3 | PC | Tissue samples of human breast cancer | (100) | |
| (+Fe2+) UVPD-MS3 | PC | Lipid extracts of mouse pancreas tissue | (102) | |
| EIEIO | PC | Egg yolk extracts | (42) |
FA, fatty acid; GPL, glycerophospholipid; TG, triglyceride; EIEIO, electron impact excitation of ions from organics; UVPD, ultraviolet photodissociation; OzID, ozone-induced dissociation; OAD, oxygen attachment dissociation; PB, Paternò-Büchi.