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. 2022 Jun 8;13:910217. doi: 10.3389/fphar.2022.910217

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Copyright © 2022 Ji, Shi, Li, Hou, Yang, Liu, Duan, Liu, Chen and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of THSWD on CIRI. (A) The flow diagram of the experiment. (B) Picture of brain TTC staining in MCAO/R model rat. (C) Weight change before and after MCAO/R. ^* p < 0.05 versus sham group (weight loss). (D) Neurological deficit scores before drug administration. The scores were not statistically different between the groups except for the sham-operated group. (E) Neurological deficit scores after treatment. n = 15 per group. (F) Daily body weight of rats in each group. n = 15 per group. (G) Representative pictures of TTC staining. (H) Quantitative analysis of cerebral infarct volumes; n = 5 per group. ^∗ p < 0.05 versus sham group, ^*** p < 0.001 versus sham group, ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 versus MCAO/R group, ^& p < 0.05, ^&&& p < 0.001 versus MCAO/R + THWSD group.