Table 1.
Insulin/IGF growth factor system genes and INSR mRNA splicing factor genes are induced in glioblastomas
| No. | Gene name | Fold change in expression: proneural | Fold change in expression: mesenchymal |
|---|---|---|---|
| 1 | INSR | 5.6 | 4.9 |
| 2 | IGF1R | 10.4 | 11.3 |
| 3 | IGF2 | 59 | 60 |
| 4 | (CUCGBP1) CELF1 | 4.9 | 4.5 |
| 5 | HNRNPH1 | 2.9 | 2.3 |
| 6 | HNRNPA2B1 | 2.5 | 2.1 |
| 7 | SFRS1 | 2.8 | 2.4 |
For rows 1–3, TCGA data mining for genes involved in the insulin/IGF growth factor system reveals higher expression of INSR, IGF1R, and IGF2 in proneural and mesenchymal subtypes versus normal astrocytes (proneural: n = 31, mesenchymal: n = 55). For rows 4–7, TCGA data mining for enzymes involved in INSR mRNA splicing in proneural and mesenchymal subtypes (proneural: n = 31, mesenchymal: n = 55). Data represent the mean of all values.