Table 4.
Univariate analysis of OS and PFS based on MRS metabolic characteristics and inflammation index.
| Variables | OS | PFS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Cho | ||||||
| ≤2.50 >2.50 |
Reference 1.223 |
0.696-2.150 | 0.484 | Reference 1.551 |
0.902-2.665 | 0.113 |
| Cr | ||||||
| ≤0.50 >0.50 |
Reference 0.641 |
0.155-2.648 | 0.539 | Reference 0.501 |
0.121-2.074 | 0.341 |
| NAA | ||||||
| ≤1.50 >1.50 |
Reference 0.896 |
0.325-2.472 | 0.832 | Reference 1.188 |
0.477-2.960 | 0.712 |
| Cho/Cr | ||||||
| ≤1.50 >1.50 |
Reference 2.140 |
1.230-3.723 | 0.007 | Reference 2.863 |
1.586-5.169 | <0.001 |
| Cho/NAA | ||||||
| ≤3.50 >3.50 |
Reference 1.485 |
0.903-2.442 | 0.119 | Reference 1.619 |
0.995-2.633 | 0.052 |
| Neutrophil | ||||||
| ≤6.13 >6.13 |
Reference 1.682 |
0.993-2.849 | 0.053 | 1.581 | 0.935-2.671 | 0.087 |
| Lymphocyte | ||||||
| ≤2.70 >2.70 |
Reference 1.507 |
0.717-3.170 | 0.280 | Reference 1.441 |
0.727-2.858 | 0.296 |
| Platelet | ||||||
| ≤169 >169 |
Reference 1.336 |
0.794-2.246 | 0.275 | Reference 1.361 |
0.812-2.280 | 0.242 |
| SII | ||||||
| ≤480 >480 |
Reference 2.513 |
1.445-4.370 | 0.001 | Reference 2.297 |
1.370-3.851 | 0.002 |
| NLR | ||||||
| ≤2.50 >2.50 |
Reference 1.296 |
0.769-2.187 | 0.330 | Reference 1.182 |
0.724-1.929 | 0.503 |
| PLR | ||||||
| ≤91.50 >91.50 |
Reference 1.854 |
1.053-3.265 | 0.033 | Reference 2.211 |
1.261-3.876 | 0.006 |
OS, overall survival; PFS, progression-free survival; HR, hazard ratio; CI, confidence interval; Cho, choline; Cr, creatine; NAA, N-acetyl-aspartate; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; SII: Systemic immune-inflammation index.