Table 2.
Sofia Performance in Symptomatic and Asymptomatic Children According to Duration of Symptoms Before Test, Age, and Exposure to SARS-CoV-2
| Sensitivity | Specificity | Positive Predictive Value, % (CI) | Negative Predictive Value, % (CI) | Percent Agreement, % | |
|---|---|---|---|---|---|
| Symptomatic children (no., %) | |||||
| Days of symptoms before test | |||||
| ≤3 days | 27/32 (84; CI, 68-93) | 154/155 (99; CI, 96-100) |
96 (82-100) | 97 (93-99) | 181/187 (97) |
| 4-5 days | 7/10 (70; CI, 40-89) | 39/40 (98; CI, 87-100) |
88 (53-99) | 93 (81-98) | 46/50 (92) |
| Alla | 36/44 (82; CI, 68-91) | 203/205 (99; CI, 97-100) |
95 (83-99) | 96 (93-98) | 239/249 (96) |
| Age | |||||
| 0-5 years | 17/21 (81; CI, 60-92) | 114/116 (98; CI, 94-100) |
90 (67-98) | 97 (92-99) | 131/137 (96) |
| 6-10 years | 4/5 (80; CI, 38-99) | 57/57 (100; CI, 94-100) |
100 (51-100) | 98 (91-100) | 61/62 (99) |
| 11-16 years | 15/18 (83; CI, 61-94) | 32/32 (100; CI, 89-100) |
100 (80-100) | 91 (78-97) | 47/50 (95) |
| Asymptomatic children (no., %) | |||||
| All children | 9/14 (64; CI, 39-84) | 123/124 (99; CI, 96-100) |
90 (60-100) | 96 (91-98) | 132/138 (96) |
| Children with known exposure | 8/12 (67; CI, 39-86) | 103/104 (99; CI, 95-100) |
89 (57-99) | 96 (91-99) | 111/116 (96) |
Abbreviation: CI, confidence interval.
Group inclusive of above as well as 12 additional children who did not have the exact number of symptom days reported.