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. 2022 May 27:jiac218. doi: 10.1093/infdis/jiac218

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© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

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Figure 1. — BALF transcriptome profile for CARDS patients: (A) experimental setup; (B) PC analysis depicting the 3 patient groups; and (C) Venn diagram representing the DE gene relationship for CARDS without DXM treatment and CARDS with DXM treatment compared to controls. Arrows pointing up depict upregulated DE genes, and arrows pointing down depict downregulated DE genes. D, Table of number of differentially expressed genes. The number of up- or downregulated genes for CARDS patients is not a sum of up- or downregulated genes of the 2 subgroups (with [+] and without [−] DXM treatment) as the differential expression analyses are independent. B and C, The color coding represents patient groups. Abbreviations: ARDS, acute respiratory distress syndrome; BAL, bronchoalveolar lavage; CARDS, COVID-19–associated acute respiratory distress syndrome; DE, differentially expressed; DXM, dexamethasone; PC, principal component; RML, right middle lobe.