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. 2022 May 27:jiac218. doi: 10.1093/infdis/jiac218

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© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

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Figure 2. — Gene ontology analysis and ISG regulation in CARDS patients. A, Gene ontology (biological process) analysis of upregulated DE genes for CARDS with DXM treatment. Adjusted P value set to P < .05 and only categories where DE genes accounts for more than 20% of total with 10 or more genes in the category displayed. X-axis shows the number of DE genes upregulated in each category. B, Heatmap of 42 differentially expressed ISGs showing expression z-scores. The 42 ISGs were identified from a list of 399 known ISGs [7]. Rows represent individual ISGs and columns individual patients with patient IDs shown below. Abbreviations: CARDS, COVID-19–associated acute respiratory distress syndrome; DE, differentially expressed; DXM, with (+) and without (−) dexamethasone; ISG, interferon-stimulated gene.