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Study design. Schematic representation of the timeline of immune monitoring of the clinical study. Abbreviations: RBD, receptor binding domain; T0, before vaccination; T1, after 3–4 weeks from T0; T2, 5–8 weeks from T0; Tpre-3D. 5 months from T2; Tpost-3D, 2-4 weeks from Tpre-3D.
