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. 2022 Jul 7;76(3):e426–e438. doi: 10.1093/cid/ciac404

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Kinetic of humoral response after 2 and 3 doses of vaccine in diseases groups. A, The level of the anti-RBD antibody was compared in HM (green dots), ST (red dots), ID (blue dots), ND (black dots), and HCW (gray dots) at 3 different time points: after 2 doses (T2) and before (pre-3D) and after (post-3D) the booster dose. Differences were evaluated by Wilcoxon paired test. HM: median T2: 3.4 BAU/mL (IQR 0.1-238.8 BAU/mL); median pre-3D: 0.3 BAU/mL (IQR 0.1-8.1 BAU/mL); median post-3D: 3.6 BAU/mL (IQR 0.1-555.6 BAU/mL). **P < .001. ST: median T2: 2089 BAU/mL (IQR 956.7–3652.0 BAU/mL); median pre-3D: 158.1 BAU/mL (IQR 58.0–444.6 BAU/mL); median post-3D: 4093 BAU/mL (IQR 1051.0–5769.0 BAU/mL). *P < .05; ****P < .0001. ID: median T2: 3.7 BAU/mL (IQR 0.15–400.4 BAU/mL); median pre-3D: 6.6 BAU/mL (IQR 0.2–59.9 BAU/mL); median post-3D: 694.0 BAU/mL (IQR 150.0–1356.0 BAU/mL). ***P < .001. ND: median T2: 107.0 BAU/mL (IQR 7.8–1510.0 BAU/mL); median pre-3D: 32.6 BAU/mL (IQR 9.3–151.9 BAU/mL); median post-3D: 443.0 BAU/mL (IQR 48.0–1770.0 BAU/mL). **P < .01, ****P < .0001. HCW: median T2: 2646.0 BAU/mL (IQR 1529.0–3958.0 BAU/mL); median pre-3D: 60.20 BAU/mL (IQR 39.3–93.5BAU/mL); median post-3D: 4608.0 BAU/mL (IQR 3302.0-6030.0 BAU/mL). ****P < .0001. B, The level of the neutralizing antibody was compared in HM (green dots), ST (red dots), ID (blue dots), ND (black dots), and HCW (gray dots) at 3 different time points: after 2 doses (T2) and before (pre-3D) and after (post-3D) the booster dose. Differences were evaluated by Wilcoxon paired test. HM: median T2: 20 reciprocal of dilution (IQR 5–60); median pre-3D: 5 reciprocal of dilution (IQR 5–7.5); median post-3D: 60 reciprocal of dilution (IQR 5–560). ST: median T2: 160 reciprocal of dilution (IQR 80–320); median pre-3D: 10 reciprocal of dilution (IQR 6.2–40.0); median post-3D: 320 reciprocal of dilution (IQR 80–640). **P < .01, ***P < .001, ****P < .0001. ID: median T2: 15 reciprocal of dilution (IQR 5–100); median pre-3D: 5 reciprocal of dilution (IQR 5–20); median post-3D: 120 reciprocal of dilution (IQR 12.5–320). *P < .05, **P < .01. ND: median T2: 40 reciprocal of dilution (IQR 5–160); median pre-3D: 5 reciprocal of dilution (IQR 5–40); median post-3D: 160 reciprocal of dilution (IQR 80–320). **P < .01, ***P < .001. HCW: median T2: 160 reciprocal of dilution (IQR 80–160); median pre-3D: 5 reciprocal of dilution (IQR 5–10); median post-3D: 320 reciprocal of dilution (IQR 160-640). **** P < .0001. C, The level of anti-RBD antibodies at Tpost-3D was compared among groups and was expressed as BAU/mL. Differences were evaluated by Kruskal-Wallis test. *P < .05; **P < .01; ****P < .0001. HM: median = 3.6 BAU/mL (IQR .1-555.6 BAU/mL); ST: 4093.0 BAU/mL (IQR 1051.0–5769.0 BAU/mL); ID: 694.0 BAU/mL (IQR 150.0–1356.0 BAU/mL); ND: 443 BAU/mL (IQR 48.1–1770.0 BAU/mL) and HCW: 4608.0 BAU/mL (IQR 3302.0–6030.0 BAU/mL, respectively). D, The level of neutralizing antibodies at Tpost-3D was compared among groups and was expressed as reciprocal of dilution. Differences were evaluated by Kruskal-Wallis test. *P < .05. HM: median = 60 reciprocal of dilution (IQR 5–560); ST: 320 reciprocal of dilution (IQR 80–640); ID: 120 reciprocal of dilution (IQR 12.5–320); ND: 160 reciprocal of dilution (IQR 180–320) and HCW: 320 reciprocal of dilution (IQR 160–640, respectively). E, The percentage of patients (HM, green dot; ST, red dots; ID, blue dots; ND, black dots; HCW, white dots) presenting a positive anti-RBD response (>7.1 BAU/mL) at T2, before (pre-3D) and after (post-3D) the booster dose is shown. F, The correlation between the levels of anti-RBD and neutralization titer at T post-3D for all fragile patients is shown. Each black dot represents 1 sample. Spearman test: rho: .8965, P < .0001). Abbreviations: HCW, health care workers; HM, hematological malignancies; ID, immune-rheumatological diseases; IQR, interquartile range; ND, neurological disorders; ST, solid tumors; T2: 5–8 weeks from T0; Tpre-3D, 5 months from T2; Tpost-3D, 2–4 weeks from Tpre-3D.