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. 2022 May 26:jiac215. doi: 10.1093/infdis/jiac215

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© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

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Figure 1. — Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant spike binding immunoglobulin G (IgG), pseudovirus neutralizing, and antibody-dependent cell-mediated cytotoxicity (ADCC) antibody responses in children. A, Binding IgG titers to SARS-CoV-2 variant spike proteins were measured using a MesoScale Discovery V-PLEX assay and reported in World Health Organization/NIBSC units (binding antibody units [BAU]/mL). B, Pseudovirus neutralizing antibody titers to the SARS-CoV-2 spike variants were expressed as the estimated concentration at which 50% pseudoviruses were neutralized (EC50). C, The ADCC antibody responses to SARS-CoV-2 variants were expressed as end-point titers. One child in the multisystem inflammatory syndrome in children (MIS-C) cohort had insufficient sample volume for binding IgG analysis. Each dot represents 1 tested specimen. The dashed line represents the lower limits of detection for each respective variant and assay. Unpaired, 2-tailed t tests were performed for statistical comparisons. *, P < .05; **, P < .01; ***, P < .001; ****, P < .0001. NS, not significant.