Table 1.
Effect of SIT on signaling pathways of apoptosis, cell cycle, and metastasis.
| Mechanism | Tumor cell/tissue type | Dosage/ concentrations | Signaling pathways | REF |
|---|---|---|---|---|
| Apoptosis | NCI-H460 | 200 μM | P53, pSer15-p53, and p21 | (17) |
| NSCLC | 200 μM | Trx/TrxR1 | (17) | |
| MCF-7 and MDA-MB-231 | 196.28 ± 4.45 μM(EC50) | PI3K/Akt/mTOR | (18) | |
| Caski and HeLa | 20 µmol/L | p53 mRNA and HPV E6 | (19) | |
| Calu-6 | P53 | (20) | ||
| MCF-7, HTC116, and HeLa | 13 μM | P53 mRNA | (21) | |
| SGC-7901 | 2.5 μg/ml | P-ERK1/2 and Bcl-2 | (23) | |
| U937 | 20 μM | Caspase-3 and Bcl-2 | (24) | |
| U937 and HL60 | >20 μM | Bcl-2 and PI3K/Akt | (26) | |
| MDA-MB-231 | 30-90 μM | Bax/Bcl-2 | (27) | |
| ES2 and OV90 | 50 µg/mL | Bax and Bak | (28) | |
| SGC-7901 | Bcl-2/Bax | (29) | ||
| OV90 | 50 µg/mL | ROS | (28) | |
| HepG2 | 70 μmol/L | (31) | ||
| SK-Hep-1 and HepG2 | 123.12 ± 3.51 μM and 140 ± 4.21 μM(IC50) | Bcl-2 | (32) | |
| AGS | 100 μg/ml | AMPK | (37) | |
| Proliferation | AGS | P53 | (39) | |
| SiHa | (42) | |||
| MDA-MB-231 | 30-90 μM | CyclinD1 and CDK4 | (27) | |
| A549 | 10 mg/ml | TGF-β/Smad2/3/c-Myc | (45) | |
| Kidney tissue | 20 mg/kg bw | MAPK | (48) | |
| COLO 320DM | 20 mg/kg bw | PCNA | (51) | |
| Metastasis | U266 | VEGF | (55) | |
| H22 | 50 mg/kg bw | VEGF and IFN-γ | (56) | |
| Rat aortic microvessels | 4.34 ± 1.64 μg/mL | VEGF | (57) | |
| Alveolar epithelial cell | 1-10 μg/mL | TGF-β1/Snail | (60) | |
| MIA-PaCa-2 and BXPC-3 | 250 μM/L | AKT/GSK-3β | (61) | |
| PC-3 and DU-145 | 120 μM(IC30) | CDH1 | (63) | |
| MCF-7 and MDA-MB-231 | 60 μM(IC30) | CDH1 | (64) |