Table 3.

SIT acts synergically with other chemotherapeutic drugs.

Standard anti-cancer drugs	Dosage/ concentrations	Tumor cell type	Signaling pathways	Mechanism	REF
PLX4720	20 mg/kg bw	Melanoma cell		proliferation	(81)
Cisplatin	50 µg/mL	ES2 and OV90	PI3K and MAPK	proliferation	(28)
Taxol	50 µg/mL	ES2、OV90	PI3K、MAPK	proliferation	(28)
Cyclophosphamide	100 mg/kg bw	HepG2	IL-2 and IL-10	Improved immunity	(80)
Oxaliplatin	100 mg/kg bw	CRC	P53/NF-κB/BCRP	Expression of drug-resistant protein was inhibited	(85)
Tamoxifen	16 µM	MCF-7 and MDA-MB-231	CER	proliferation	(86)
Gemcitabine	80 mg/kg bw	MIAPaCa-2 and BXPC-3	NF-κB, Bax, and Bcl-2	Induced cell cycle arrest and apoptosis	(87)