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Metabolic regulation of HSCs. Young hematopoitic stem cells have a higher mitochondrial mass, but the mitochondria are inactive, and the cells rely on glycolysis. However, under stress, increase in metabolic activity, OXPHOS (oxidative phosphorylation) and FAO (fatty acid oxidation) lead to impaired stem cell function. This phenomenon can be reversed by increasing mitochondrial membrane potential (MMP).
