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Metabolic difference between AML and CML LSCs. AML LSCs are reliant on OxPhos and yet have low ROS level controlled by mitophagy. Moreover, AML LSCs use amino acid and fatty acid metabolism to fuel the citric acid cycle. CML LSCs on the other hand exhibit increased mitochondrial biogenesis, FAO, OXPHOS and ROS. ROS leads to DNA instability and subsequently. Causes mutation in the BCR-ABL oncogene, rendering the cells resistant to drug treatment.
