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. 2022 Jun 8;13:896628. doi: 10.3389/fphar.2022.896628

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Copyright © 2022 Ren, Zhang, Tao, Chen, Zou, Guo, Shen, Feng and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of PKA antagonist H89 on the antidepressant response after a single GJ-IFM treatment. (A) The effect of H89 pretreatment on immobility time in TST 30 min after GJ-IFM treatment in KM mice. One-way ANOVA, p > 0.05, GJ-IFM vs. GJ-IFM + H89. (B) The effect of H89 pretreatment on immobility time in TST 2 h after GJ-IFM treatment in KM mice. One-way ANOVA, p > 0.05, GJ-IFM vs. GJ-IFM + H89. (C) The effect of H89 pretreatment on immobility time in TST 1 d after GJ-IFM treatment in KM mice. One-way ANOVA, ^△△△ p < 0.001, GJ-IFM vs. GJ-IFM + H89. (D) The effect of H89 pretreatment on immobility time in FST at 26 h after GJ-IFM treatment in KM mice. One-way ANOVA, ^△ p < 0.05, GJ-IFM vs. GJ-IFM + H89.