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. 2022 Jun 8;12:903832. doi: 10.3389/fonc.2022.903832

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Copyright © 2022 Aiswarya, Vikas, Haritha, Liju, Shabna, Swetha, Rayginia, Keerthana, Nath, Reshma, Sundaram, Anto, Lankalapalli, Anto and Bava

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ECF, a bioactive fraction of C. epigaeus rhizome induces cytotoxicity in melanoma cells (A–C) Cytotoxicity assessment of the C. epigaeus rhizome-derived organic extracts on cancer cells of various tissue origins. (D) Cell viability analysis upon treatment by ECF bioactive fraction as assessed in various cancer cell lines. (E, F) Cytotoxicity induced by ECF on melanoma cell lines in comparison to normal skin fibroblast, FS cells. (G) ECF inhibits the proliferative potential of A375 cells. Data are representative of three independent experiments (Mean±SEM) and P-values are calculated using one way ANOVA. ***P ≤0.001, **P ≤0.01 and ns ≥ 0.05.