. 2022 Jun 8;10:911232. doi: 10.3389/fchem.2022.911232

TABLE 1.

Inhibition of OA analogs (4a–4s) on α-glucosidase and α-amylase.


Compound	R	α-glucosidase inhibition (IC₅₀ μM)	α-amylase inhibition (IC₅₀ μM)
4a		1.90 ± 0.31 ^a ^, ^b	41.23 ± 2.99 ^a ^, ^b
4b		0.61 ± 0.09 ^a ^, ^b	19.80 ± 1.22 ^a ^, ^b
4c		0.86 ± 0.05 ^a ^, ^b	51.12 ± 2.55 ^a ^, ^b
4d		2.41 ± 0.08 ^a ^, ^b	62.18 ± 1.89 ^a ^, ^b
4e		1.92 ± 0.13 ^a ^, ^b	20.53 ± 2.29 ^a ^, ^b
4f		1.63 ± 0.10 ^a ^, ^b	60.27 ± 1.88 ^a ^, ^b
4g		3.96 ± 0.21 ^a ^, ^b	59.09 ± 1.98 ^a ^, ^b
4h		0.83 ± 0.04 ^a ^, ^b	18.52 ± 1.39 ^a ^, ^b
4i		0.40 ± 0.02 ^a ^, ^b	20.27 ± 2.18 ^a ^, ^b
4j		1.23 ± 0.07 ^a ^, ^b	15.68 ± 1.53 ^a ^, ^b
4k		0.88 ± 0.04 ^a ^, ^b	45.41 ± 2.16 ^a ^, ^b
4l		0.45 ± 0.02 ^a ^, ^b	19.39 ± 0.73 ^a ^, ^b
4m		1.73 ± 0.16 ^a ^, ^b	20.49 ± 1.09 ^a ^, ^b
4n		0.72 ± 0.06 ^a ^, ^b	16.75 ± 1.04 ^a ^, ^b
4o		0.52 ± 0.02 ^a ^, ^b	9.59 ± 0.58 ^a ^, ^b
4p		1.18 ± 0.14 ^a ^, ^b	19.51 ± 1.85 ^a ^, ^b
4q		1.17 ± 0.10 ^a ^, ^b	20.20 ± 1.20 ^a ^, ^b
4r		1.08 ± 0.04 ^a ^, ^b	20.77 ± 1.88 ^a ^, ^b
4s		1.22 ± 0.14 ^a ^, ^b	55.56 ± 2.52 ^a ^, ^b
OA		4.09 ^a	94.10 ^a
Acarbose		665.56 ^b	100.01 ^b

Indicating comparisons between the compound group with the OA group (P < 0.05)

Indicating comparisons between the compound and OA groups with the acarbose group (P < 0.05).