TABLE 1.

Inhibitory activities of 2,5-substituted furan derivatives 1a–k against PRMT1.

Cpd no.	Cpd ID.	R1	R 2	% Inhibition of PRMT1 (at 10 μM) a	IC50 (μM)
—	SAH	—	—	—	0.55 ± 0.07
—	DB75	—	—	98.13 ± 0.27	0.31 ± 0.04
1a	ZZQ-16	H	-CONH2	10.61 ± 2.24	—
1b	ZZQ-82	H	-CONHNH2	48.00 ± 0.02	—
1c	ZZQ-55	H	-NH2	50.00 ± 0.18	21.42 ± 12.76
1d	ZZQ-52	-NH2	H	35.99 ± 0.09	—
1e	ZZQ-102	H		32.00 ± 0.00	—
1f	ZZQ-127	F		35.97 ± 0.20	—
1g	ZZQ-100		H	39.98 ± 0.19	—
1h	SYT-302	H		74.54 ± 0.16	2.66 ± 0.01
1i	SYT-298	F		68.00 ± 0.02	4.42 ± 0.63
1j	SYT-290		H	76.82 ± 1.19	2.06 ± 0.60
1k	SYT309		Cl	76.50 ± 0.01	2.50 ± 0.91

^aInitial inhibition rate was tested at 10 μM for all compounds, and only those with >50% inhibition effects were selected for IC₅₀ measurements.