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Inhibitory activities of 2,5-substituted furan derivatives 1l–o against PRMT1.
| |||||
| Cpd no. | Cpd ID. | R1 | R2 | % Inhibition of PRMT1 (at 10 μM) | IC50 (μM) |
| — | SAH | — | — | — | 0.55 ± 0.07 |
| — | DB75 | — | — | 98.13 ± 0.27 | 0.31 ± 0.04 |
| 1l | WCJ-237 | -CH3 | -CH3 | 92.12 ± 0.28 | 1.29 ± 0.12 |
| 1m | WCJ-163 |
|
-CH3 | 48.00 ± 0.02 | 10.78 ± 1.30 |
| 1n | WCJ-77 | -CH2CH2 | 73.51 ± 0.06 | 4.68 ± 0.26 | |
| 1o | WCJ-173 | -CH3 | H | 89.02 ± 0.05 | 2.41 ± 0.18 |
