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Inhibitory activities of 2,4-substituted thiazole derivatives 1p–r against PRMT1.
| |||||
| Cpd no. | Cpd ID. | X | R | % Inhibition of PRMT1 (at 10 μM) | IC50 (μM) |
| — | SAH | — | — | — | 0.55 ± 0.07 |
| — | DB75 | — | — | 98.13 ± 0.27 | 0.31 ± 0.04 |
| 1p | WCJ-141 | C | -CH3 | 87.00 ± 0.00 | 1.49 ± 0.47 |
| 1q | WCJ-172 | N | -CH3 | 75.71 ± 0.82 | 4.14 ± 0.34 |
| 1r | WCJ-394 | N | H | 98.50 ± 0.04 | 1.21 ± 0.11 |
