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Reduced density of neurons in post-mortem Down syndrome cortex
(A) Representative images of NeuN+, PV+, and CR+ neurons detected by immunohistochemistry (DAB) in control and DS post-mortem superior temporal gyrus (STG) samples.
(B) Stereological quantification of the density of each neuron subtype in control and Down syndrome (DS) tissue. N = 4; NeuN ∗p = 0.03, PV p = 0.89, CR p = 0.11 calculated using non-parametric Mann-Whitney U test.
