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. 2022 Jan 6;12(6):2887–2904. doi: 10.1016/j.apsb.2021.12.023

Figure 6.

Figure 6

GPS promoted the formation of the PI3K dimer complex (p110α–p85α) in liver tissue by inhibition of PAQR3. (A) Representative Western blots results and densitometric analysis of PAQR3 and p-PI3K in liver tissues (n = 3). (B) Representative Western blot results and densitometric analysis of PAQR3 and P110α in Golgi apparatus of liver tissue (n = 3). (C) Immunofluorescence staining presents the distribution and co-location of PAQR3 and P110α in liver tissue. Scale bar = 20 μm. (D) A co-immunoprecipitation assay was performed to detect the interaction between PAQR3 and p110α in liver tissue. (E) The interaction between P110α and P85α in liver tissue was detected by co-immunoprecipitation. The data are presented as mean ± SD, all experiments were performed at least three times with similar results. ∗∗∗P < 0.001, ∗∗P < 0.01 vs. control group; ##P < 0.01, #P < 0.05 vs. diabetes group; ns means no significance.