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The selectivity of YPD-29B on different immune checkpoints.
| Immune checkpoint | IC50 (nmol/L) |
|
|---|---|---|
| YPD-29B | Positive control | |
| hPD-1/hPD-L1 | 0.32 | 2.2 (PD-1 antibody) |
| hB7-1/hPD-L1 | 0.3 | 2.5 (PD-L1 antibody) |
| mPD-1/mPD-L1 | >10,000 | 2.7 (mPD-L1 antibody) |
| hPD-1/hPD-L2 | >10,000 | 2.2 (PD-1 antibody) |
| hCD28/hB7-1 | >10,000 | 7.8 (CTLA4 Fc) |
| hCD28/hB7-2 | >10,000 | 13 (CTLA4 Fc) |
| hCTLA4/hB7-1 | >10,000 | 2.8 (CTLA4 antibody) |
| hCTLA4/hB7-2 | >10,000 | 5.3 (CTLA4 antibody) |
| LAG3/MHC IIa | >10,000 | 30 (LAG3 antibody) |
HTRF.
