Table 2.
The affinity of YPD-29B in different species of PD-L1.
Affinity | Rat |
Cynomolgus monkey |
Human |
|||
---|---|---|---|---|---|---|
YPD-29B | rPD-L1mab | YPD-29B | cmPD-L1mab | YPD-29B | hPD-L1mab | |
Ka (1/ms) | 2.02 × 10−5 | 6593 | 2.34 × 10−6 | 7.15 × 10−4 | 1.53 × 10−6 | 3.28 × 10−6 |
Kd (1/s) | 5.59 × 10−3 | 5.60 × 10−4 | 2.02 × 10−4 | 5.74 × 10−4 | 5.60 × 10−5 | 2.82 × 10−4 |
KD (mol/L) | 2.77 × 10−8 | 8.49 × 10−8 | 8.64 × 10−11 | 8.03 × 10−9 | 3.67 × 10−11 | 8.58 × 10−11 |
Rmax (RU) | 5.33 | 306.10 | 27.18 | 94.82 | 31.99 | 47.28 |