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. 2022 Mar 17;12(6):2751–2777. doi: 10.1016/j.apsb.2022.03.009

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Fig. 2 — Multi-phase kinetics of CAR-T cell and model structure. (a) A typical multi-phase kinetics of CAR-T cell: distribution, expansion, contraction and persistence phase; (b) model structure for CAR-T kinetics; (c) schematic diagram of a three-step workflow for modeling and analysis. ALL, acute lymphocytic leukemia; CAR-T, chimeric antigen receptor-T; CLL, chronic lymphocytic leukemia; C_max, peak plasma concentration; CR/PD, complete response/progressive disease; DLBCL, diffuse large-B cell lymphoma; MM, multiple myeloma. Reproduced with permission from Ref. 267. Copyright © 2020 The authors and American Society for Clinical Pharmacology and Therapeutics.