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. 2021 Dec 17;12(6):2808–2831. doi: 10.1016/j.apsb.2021.12.006

Table 2.

Summary of recent small molecules for HSC expansion.

Compd.	Reported in	Target	Expansion effect	SRC expansion	Ref.
SW033291	2015	15-PGDH	‒	2.4-fold	79
DJ001	2019	PTPσ	4.07-fold LSK	‒	83
C7	2018	p38	3.7-fold CD34⁺38⁻45⁺45RA⁻	2.9-fold	87
JNK-IN-8	2019	JNK	8-fold CD34⁺38⁻45RA⁻90⁺	3.88-fold	91
005A	2015	p18	^aED₅₀ 5.21 nmol/L	2.72-fold	98
CPI-203	2020	BET	5–10 folds HSCs	5‒10-fold	99
GW9662	2018	PPAR-γ	7-fold CD34⁺CD38⁻	5-fold	101
Alexidine	2015	Ptpmt1	‒	∼2-fold	103
OAC1	2016	OCT4	2.2-fold CD34⁺CD38⁻ 2.8-fold HSCs	6.3-fold	106
NR101	2009	TPO	2.3-fold CD34⁺CD38⁻	2.3-fold	107
Eltrombopag	2018	TPO	‒	1.7-fold	108
BIO	2011	GSK-3	2-fold CFU activity	‒	111
CHIR99021	2005, 2012	GSK-3	7-fold TNC	5-fold	109,112
VPA	2005	HDAC	CD34⁺ cell numbers↑	6-fold	121,122
LMK235	2018	HDAC5	‒	4.3-fold	130
5azaD	2006	DNMT	2.5-fold CD34⁺ 40-fold CD34⁺CD90⁺	‒	132
zVADfmk/zLLYfmk	2010	Cysteine protease	3-fold CD34⁺CD38⁻	–	135
DEAB	2006	ALDH	11.6-fold^b CD34⁺CD38⁻	3.4-fold	136

^a

Determined as the ratio of CFU-nmEM colonies.

^b

Relative to input, others without note are relative to control.