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. 2022 Feb 16;12(6):2658–2671. doi: 10.1016/j.apsb.2022.02.009

Figure 1.

Figure 1

Characterizations of SPP-ARV-825 micelle. Molecular dynamic simulations of the interaction between mPEG-PDLLA and ARV-825 in (A) water environment (pH = 7) and (B) tumor-mimicking environment (pH = 6.5). Conformations (I), (II), (III), (IV), (V), and (VI) represented the snapshots of the interaction between mPEG-PDLLA and ARV-825 at 0, 2, 4, 6, 8 and 10 ns, respectively. (C) Particle size distribution of SPP-ARV-825. (D) Zeta potential of SPP-ARV-825. (E) TEM image of SPP-ARV-825 (scale bar = 50 nm). (F) The cumulative release of ARV-825 from SPP-ARV-825 micelle (the black line indicated free agent of ARV-825).