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. 2022 Feb 16;12(6):2658–2671. doi: 10.1016/j.apsb.2022.02.009

Figure 5.

Figure 5

SPP-ARV-825 enhanced inhibition of cells proliferation and angiogenesis, and induction of apoptosis in GL261 subcutaneous tumor. (A) Representative Ki67 staining images of tumors form different therapeutic groups (scale bar = 50 μm). (B) Representative CD31 staining images of tumors form different therapeutic groups (scale bar = 50 μm). (C) Representative TUNEL staining images of tumors from different therapeutic groups (blue: cell nuclei; green: apoptosis cells, scale bar = 50 μm). (D–F) Statistical analysis of (D) Ki67-positive cells, (E) microvessels number per field and (F) apoptosis cells in different groups (n = 4). Data are presented as mean ± SEM. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 and ∗∗∗∗P < 0.0001.