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. 2022 Feb 16;12(6):2658–2671. doi: 10.1016/j.apsb.2022.02.009

Figure 7.

Figure 7

ARV-825-mediated suppression of IL4-induced M2 macrophages polarization. (A) Heatmap of statistically significant (FDR < 0.05) differentially gene expression in different treated macrophages by RNA-seq profiling. (B) Heatmap of statistically significant (FDR < 0.05) differentially gene expression related to M2 macrophages in different treatments. (C) RT-qPCR detection of mRNA expression related to M2 macrophages (Fizz1, Ym1, Arg1, IRF4, Mrc1, CCL17, CCL22, IL10) in BMDMs after different treatments (n = 3). (D) Western blot analysis of M2 macrophages-related proteins expression (Fizz1, Ym1, IRF4 and Arg1). Data are presented as mean ± SEM. ∗∗P < 0.01, ∗∗∗P < 0.001 and ∗∗∗∗P < 0.0001.