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. 2022 Mar 4;12(6):2905–2922. doi: 10.1016/j.apsb.2022.02.029

Table 2.

Kinase inhibitory activities of compounds 10–29 against PAK4.

Image 10
Compd. R2 PAK4 Ki (μmol/L)a Compd. R2 PAK4 Ki (μmol/L)a Compd. R2 PAK4 Ki (μmol/L)a
10 Image 11 0.623 17 Image 18 0.157 24 Image 25 0.298
11 Image 12 0.223 18 Image 19 0.242 25 Image 26 0.189
12 Image 13 0.355 19 Image 20 0.212 26 Image 27 0.083
13 Image 14 0.291 20 Image 21 0.396 27 Image 28 >10
14 Image 15 7.455 21 Image 22 0.173 28 Image 29 0.680
15 Image 16 0.217 22 Image 23 0.709 29 Image 30 1.109
16
 Image 17 0.105 23 Image 24 0.230
a

PAK4 kinase inhibition was determined using a homogeneous time-resolved fluorescence (HTRF) assay. The Ki values are the average of two independent experiments, reported as the mean value.